摘要
目的观察两种不同提取工艺所得到的吴茱萸提取物对正常大鼠血压的影响。方法用BL-420E生物机能实验系统测定吴茱萸提取物对正常大鼠血压的影响,持续观察240min。结果十二指肠给予吴茱萸水蒸馏液1ml/ 100g(相当于生药10g/kg)后,表现出明显降压效应,最大降压幅度约47.03%。给予0.5ml/100g(相当于生药5g/ kg)的吴茱萸水蒸馏液后,降压作用不明显。直接用75%乙醇提取得到的总碱以相当于生药10g/kg给药后,血压无明显变化。结论吴茱萸的水蒸馏液对正常大鼠有降压作用,而总碱降压作用则不显著。
Objective To observe effect of extracts from euodia rutaecarpa (ER) by two different extraction crafts on blood pressure (BP) in normal rats. Methods Blood pressure of rats was determined by biological function experimental system, that was administrated by extrac. from ER. Results 10ml/kg water distillation liquid (WER), is about 10g /kg crude drug, was administrated by dodecadactylon (duodenum). SP and DP was obviously decreased. The depres-surization of blood pressure was last about 4h and maximum effect was 47.03%. After administrating 10ml/kg total alkali extracted of ER by etHano1.75% (AER), BP was not significally change. Conclusions The study shows that WER can depress blood pressure, but not AER in normal rats.
出处
《合肥医学院学报》
2005年第1期4-6,共3页
Journal of Zunyi Medical University
基金
贵州省卫生厅基金
(NO D-185)
关键词
吴茱萸
提取物
提取工艺
血压
大鼠
euodia rutacecarpa
extract
extraction craft
blood pressure
rat
