摘要
本实验观察了海螵蛸对大鼠胃液分泌、胃壁结合粘液量和胃运动的影响，测定了应用海螵蛸后胃组织ｃＡＭＰ、前列腺素Ｅ２（ＰＧＥ２）和ＤＮＡ含量的变化。结果表明，海螵蛸２００ｍｇ灌胃及与胃液在体外反应均能降低胄液总酸度。药物２００ｍｇ１次／ｄ×１应用和连续应用１０日均能增加胄组织ｃＡＭＰ含量，而且用药１０日作用更明显。此外，还能增进胃粘膜ＰＧＥ２的合成。提示：海螵蛸系通过中和胃酸、加强细胞保护等作用途径实现其防治胃溃疡的作用。
The Os Sepiella maiudrone(OSM) could markedly iuhibit the stress-induced gastric mucosal lesions and promote the healing of acetic acid-induced gastric ulcer in rats were reported previously.In order to demonstrate its mechanism,the effects of OSM on acidity of gastric juice,combined mucus content in gastric wall,DNA synthesis,gastric movements,the gastric contents of prostaglandin E2(PGE2) and cAMP of gastric tissue were examined.The results showed that OSM could neutralize the gastric acid,promote the production of cAMP and PGE,in gastric tissue.These suggested that the neutralization of gastric acid and euliancing the gastric mucosal cytoprotection by OSM would play a role in preventing and curing gastric ulcers in rats.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第2期101-103,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
海螵蛸
前列腺素E2
细胞保护作用
Os Sepiella maiudrone,gastric acid,cAMP,prostaglandin E_2,cytoprotection
