摘要
甘草酸单铵对内毒素诱发支气管高反应性的预防作用陈剑雄，曹永舒（衡阳医学院药理教研室，衡阳４２１００１；河南医科大学药理教研室，郑州４５００５２）呼吸道感染是诱发或加剧支气管高反应性形成的重要因素，内毒素作为致病原可诱发支气管高反应性产生，其产生机理与...
Four days after endotoxin 1.0 mg·kg-1 intraperitoneal injection,the latent periods of on-set of asthma in guinea pigs inhaled histamine(His)and pD2 value of isoprenaline hydrochloride(Iso)were decreased,meanwhile pD2 value of His and Hislevels of lung tissue and plasma were increasedsignificantly.Ammonium glycyrrhizanate 50 mg.kg.d-1 ip x 4 inhibited the effect of endotoxin andincreased cortisol levels of serum.The results indicatedthat ammonium glycyrrhizanate could preventbacterial infectioninduced bronchial hyperreactivity.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1994年第3期235-236,共2页
Chinese Journal of Pharmacology and Toxicology
关键词
甘草酸单铵
内毒素
气道高反应性
ammonium glycyrrhizanate,receptors.adrenergic,beta,histamine,endotoxin,bronchial hyperreactivity
