摘要
目的:研究甲磺酸帕珠沙星在健康志愿者体内的药动学特征.方法:10名健康志愿者单剂量静脉滴注甲磺酸帕珠沙星注射剂300mg,以高效液相色谱法测定给药前及给药后8h内的血药浓度,计算其药动学参数.结果:甲磺酸帕珠沙星在健康人体内的处置符合二室开放模型,其主要药动学参数为:达峰时间Tmax(实测值)为(0.52±0.17)h,峰值血浆浓度ρmax(实测值)为(6.63±1.86)mg/L,药时曲线下面积AUC(0-8)为(13.42±2.96)h·mg/L;消除半衰期T1/2β为(1.90±0.24)h.结论:静脉滴注甲磺酸帕珠沙星后,与其他喹诺酮类药物相比其药动学特征表现为半衰期较短,血药浓度高等特点.建议静脉滴注甲磺酸帕珠沙星注射剂,300mg/次,2～3次/d,在人体内可达到有效血药浓度.
AIM: To study the pharmacokinetic characteristics of pazufloxacin mesylate in healthy volunteers. METHODS: Ten healthy volunteers received a single dose of 300 mg of pazufloxacin mesylate by intravenous injection. The plasma concentrations of pazufloxacin mesylate were determined by HPLC method. RESULTS: The concentration-time curve after administration was best fitted to two-compartments open model. The main pharmacokinetics parameters of pazufloxacin mesylate were as follows: T max, ρ max, T 1/2β, AUC (0-8) were (0.52±0.17) h, (6.63± 1.86) mg/L, (1.90±0.24) h, and (13.42±2.96) h·mg/L, respectively. CONCLUSION: Pharmacokinetic study shows that pazufloxacin mesylate has short half-life and high concentration in plasma. Effective concentration by intravenous injection can be achieved after two or three dose of 300 mg pazufloxacin mesylate per day.
出处
《第四军医大学学报》
北大核心
2005年第9期846-848,共3页
Journal of the Fourth Military Medical University
关键词
甲磺酸帕珠沙星
药代动力学
色谱法
高压液相
喹诺酮类
pazufloxacin mesylate
pharmacokinetics
chromatography, high pressure liquid
fluoroquinolone
