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急性淋巴细胞白血病患儿亚甲基四氢叶酸还原酶多态性与氨甲蝶呤毒副反应的研究 被引量:26

Relationship between the methylenetetrahydrofolate reductase C677T gene polymorphism and toxicity of HD-MTX treatment in childhood acute lymphocytic leukemia
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出处 《中华儿科杂志》 CAS CSCD 北大核心 2005年第4期302-303,共2页 Chinese Journal of Pediatrics
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  • 1顾龙君,李娟,薛惠良,汤静燕,陈静,赵惠君,陈静,叶辉,王耀平,潘慈.ALL-XH-99方案治疗儿童急性淋巴细胞白血病158例疗效分析[J].中华血液学杂志,2004,25(1):1-4. 被引量:76
  • 2Krajinovic M, Lamothe S, Labuda D, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood, 2004, 103:252-257.
  • 3Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet, 1995, 10: 111-113.
  • 4Ueland PM, Hustad S, Schneede J, et al. Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci, 2001, 22: 195-201.
  • 5Ulrich CM, Kampman E, Bigler J, et al. Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction? Cancer Epidemiol Biomarkers Prev, 1999, 8: 659-668.
  • 6Toffoli G, Russo A, Innocenti F, et al. Effect of methylenetetrahydrofolate reductase 677C→T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients. Int J Cancer, 2003, 103: 294-299.

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