摘要
目的探讨肾母细胞瘤患儿手术前后血清血管内皮生长因子(VEGF)水平的变化规律以及与肿瘤的内在联系。方法应用ELISA法检测患儿行根治性肿瘤切除术后1天、1周和3个月的血清VEGF水平,并进行6个月随访。结果与术前相比,24名肾母细胞瘤患儿血清的VEGF水平在术后第一天发生了显著的降低(P<0.01),并且在一周内保持在同样低水平。术后3个月复查发现,术后6个月内死亡的5名患儿血清VEGF水平(45.0±37.4)要高于另19名患儿(3.2±1.9)。结论肿瘤本身最有可能是VEGF高表达的来源;术后VEGF表达可能成为预测肾母细胞瘤转移和预后的重要指标之一。
Objective To investigate the expression level of the vascular endothelial growth factor (VEGF) in the Wilms' tumour in children and the relation between them. Methods ELISA was used to detect the concentration of VEGF in 24 Wilms' tumour childrens' that at 1 day,1 week and 3 months after surgical excision of the tumour. Results Compared with that before surgery, the serum VEGF fall significantly 1 day after surgery (P<0.01) and remained at the same lower level for 1 week. In the blood samples taken 3 months after surgery, VEGF levels were higher in those 5 children (45.0±37.4) who subsequently died within 6 months of surgery compared with the 19 survivors (3.2±1.9). Conclusion The tumour itself is the most likely source of VEGF; the expression of VEGF after surgery maybe an indication to predict the metastasis and prognosis of the Wilms' tumour.
出处
《实用肿瘤学杂志》
CAS
2005年第2期113-115,共3页
Practical Oncology Journal
