摘要
目的 研究胃肠道间质瘤(gastrointestinalstromaltumors,GISTs)病理诊断特征及临床治疗方法。方法 对北京大学第一医院1990年1月至2 0 0 1年8月收治的GISTs进行光镜和超微结构复检,用EnVision二部法免疫组织化学方法检测波形蛋白、CD117(c kit)、CD34等8种抗原标记物在肿瘤中的表达情况。并对其中临床资料完整的30例病人的病理特点、外科治疗及预后进行回顾性分析。结果 复检确诊GISTs 87例,占同期胃肠道肿瘤的2 % (87/30 16 ) ,30例病人中恶性2 1例,良性7例,交界性2例;恶性者10例复发,复发率为4 7% (10 /2 1) ,其中8例死亡,5年生存率为6 2 % (13/2 1)。结论 GISTs是消化道常见的原发性间叶性肿瘤,CD117、CD34等免疫标记物配合使用可确诊;恶性GISTs单纯外科手术复发率高,预后不良。
Objective To study the pathologic features and advanced clinical treatment on gastrointestinal stromal tumors (GISTs).Methods All specimens of GISTs admitted between January 1990 and August 2001 in the First Affiliated Hospital of Peking University were reexamined by light microscope and electromicroscope.Expression of 8 kinds of antigen markers was examined with En-Vision TM+ in the specimens.Pathologic characters,surgical treatment and prognosis of 30 cases with complete information were analysed.Results Eighty-seven cases of GISTs were diagnosed,which accounted for 2% of patients with gastrointestinal tumor at same time (87/3016).Among 30 cases,malignant tumors were occurred in 21 cases.Benign tumors were occurred in 7 cases.Borderline tumors were occurred in 2 cases.Ten of malignant patients recurred and the recurrence rate was 47% (10/21).Eight of them died and the survival rate of 5 years was 62% (13/21).Conclusion GISTs are the common primary mesenchymoma that arise in the wall of the digestive tract.Antigen markers,such as CD117,CD34 and so on,can be used to diagnose the disease.The recurrence rate of malignant GISTs is high and the prognosis is poor when the malignant GISTs are removed surgically without combined treatment.
出处
《中国实用外科杂志》
CSCD
北大核心
2005年第4期225-226,共2页
Chinese Journal of Practical Surgery
