摘要
目的观察重复+Gz暴露后血清中心肌损伤生化标志物浓度的变化,探讨重复+Gz暴露后是否会造成心肌损伤及其机制。方法5名被试者在载人离心机上进行了3次+Gz暴露试验,加速度增长率为3G·s-1,+Gz暴露曲线平台期持续时间15s。在+Gz暴露前及结束后次日采取静脉血检测血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)及心肌肌钙蛋白I、T浓度的变化。结果重复+Gz暴露后,血清CK、CK-MB及LDH浓度显著升高(P<0.05),但均未超出正常参考值范围。1名被试者的血清心肌肌钙蛋白I、T浓度分别升高至0.39ng·mL-1及0.14ng·mL-1,在试验结束后2周恢复至正常水平,其他4名被试者的血清心肌肌钙蛋白I、T浓度无变化。结论重复+Gz暴露导致血清心肌损伤生化标志物浓度升高,其机理可能与细胞膜通透性改变有关,1名被试者的心肌肌钙蛋白I、T浓度显著升高,提示重复高+Gz暴露可能导致该被试者心肌细胞发生可恢复性微小损伤。
Objective To observe the changes of serum biochemical markers of myocardial damage after repetitive +Gz exposure, and to explore if repetitive +Gz exposure can induce the damage and its mechanism. Methods Five fully qualified centrifuge subjects were exposed to 3 series of 15 s rapid onset runs (ROR, 3 G·s -1). Serum samples were obtained pre and post +Gz exposure for measuring myocardial enzymes, cardiac troponin I (cTnI), and cardiac troponin T (cTnT). Results After multiple +Gz exposure, the activities of creatine kinase (CK), creatine kinase isoenzyme (CK-MB), and lactic dehydrogenase (LDH) were significantly increased(P<0.05) but not exceeded the normal reference range. cTnI and cTnT levels of one subject significantly elevated to 0.39 ng·mL -1 and 0.14 ng·mL -1 respectively but unchanged for the other 4 subjects. cTnI and cTnT levels of all subjects were under 0.01 ng·mL -1 two weeks after the experiment. Conclusion Serum biochemical markers of myocardial damage were increased after multiple +Gz exposure,which may be due to the alteration of cell membrane permeability. The change of cTnI and cTnT levels in one subject suggests repetitive +Gz exposure may induce a recoverable minor cardiac damage to him.
出处
《解放军预防医学杂志》
CAS
北大核心
2005年第2期82-85,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
加速度
心肌损伤
肌酸激酶
肌酸激酶同工酶
乳酸脱氢酶
肌钙蛋白
acceleration
myocardial damage
creatine kinase
creatine kinase isoenzyme
lactic dehydrogenase
cardiac troponin
