摘要
运用L9(34)正交试验设计方法,以壳聚糖(CTS)为原材料,经α酮戊二酸一次改性合成α酮戊二酸缩壳聚糖(KCTS),经盐酸羟胺二次改性合成了羟胺α酮戊二酸缩壳聚糖(HKCTS),分别与Fe3+ 交联并负载口服茶碱药物得到KCTS Fe T 和HKCTS Fe T缓释剂,并证明了合成的这种缓释剂可以成功延长茶碱模型药物的释放时间,具有较好的缓释效果。
Chitosan (CTS) is regarded as the original material in this thesis. Chitosan α-ketoglutaric acid (KCTS) is prepared by the experiments of L_(9)(3~4) orthogonal test design methods. Hydroxamated chitosan α-ketoglutaric acid (HKCTS) is also prepared successively. As well as, the polymeric beads of KCTS-Fe-T and HKCTS-Fe-T loading oral theophylline medicine on are prepared as the sustained release of oral theophylline medicine by iron(Ⅲ) crosslinking.Theophylline is used as the loaded model drug. The generated beads prove to be successful in prolonging drug release.
出处
《化学与生物工程》
CAS
2005年第4期15-17,23,共4页
Chemistry & Bioengineering
