摘要
发现了在甲醛存在的条件下, 可溶性锰(IV)与30 余种有机物和无机物的化学发光反应. 以头孢菌素类药物(头孢曲松钠、头孢唑啉钠、头孢拉定和头孢哌酮钠)为分析对象优化了可溶性锰(IV)-甲醛-头孢菌素类药物化学发光反应的条件, 建立了测定四种头孢菌素类药物的流动注射化学发光新方法, 并将建立的方法用于药物制剂中头孢菌素类药物的含量测定.同时, 对化学发光反应的机理进行了初步探讨.
It was found that soluble manganese(IV) could react with more than 30 organic and inorganic compounds to produce strong chemiluminescence signal in the presence of formaldehyde. The reaction con- ditions were optimized and a new flow injection chemiluminescence method for the determination of four cephalosporin drugs, namely ceftriaxone sodium, cefazolin sodium, cefradine and cefoperazone sodium, was established. The method was applied to the determination of cephalosporins in pharmaceutical preparations. Meanwhile, the chemiluminescence reaction mechanism was also discussed briefly.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2005年第8期729-733,共5页
Acta Chimica Sinica
基金
国家自然科学基金(No.20275023)
陕西省自然科学基础研究(No.2002B12)资助项目.
