摘要
目的分析清远地区2003年9月至2004年4月间门诊住院患者尿液标本中大肠埃希菌的耐药性及其产超广谱β-内酰胺酶(ESBLs)情况,以便更好地指导临床用药。方法应用微生物分析系统MicroScanAutoScan-4进行鉴定,并用仪器专家系统判断可疑ESBLs菌株,用纸片扩散法表型确证试验检测ESBLs。结果尿液标本中的大肠埃希菌对亚胺培南、哌拉西林/三唑巴坦、头孢西丁的耐药性最低,分别为3%、5%、8%,而对氨苄西林/舒巴坦、头孢噻吩、哌拉西林的耐药性均>70%,产ESBLs的大肠埃希菌对亚胺培南、哌拉西林/三唑巴坦、头孢西丁的耐药性均<10%,对氨苄西林、氨苄西林/舒巴坦、头孢噻吩、环丙沙星均表现出很强的耐药性。结论尿路感染应根据抗生素敏感试验选择敏感药物进行合理用药并检测相应的产ESBLs情况。
Objective To survey the antibiotic resistance and production of extended-spectrum beta- lactamases in Escherichia coli from urine in Qingyuan area from September 2003 to April 2004. Methods The sensitivity of Escherichia coli to 20 antibiotics were tested by the Microscan AutoScan-4 and the extended spectrum β-lactamase (ESBLs) were identified by disc agar diffusion method. Results The drug resistance of Escherichia coli isolated from urine to imipenem, piperacillin/tazobactcm and cefoxitin is the least, it was 3%, 5% and 8% respectively, while the ESBLs producting Escherichia coli were all less than 10%, the drug resistance of Escherichia coli isolates to ampicillins, ampicillin/sulbactam, cephalothin and piperacillin were higher than 70%, and all were highly resistant to ampicillin, ampicillin/sulbactam, cephalothin and ciprofloxacin. Conclusions The rational use of antibiotics to treat urinary track infections should be based on the results of the antibacterial susceptibility and/or the ESBLs producing tests.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2005年第4期241-243,共3页
Chinese Journal of Antibiotics
