摘要
目的比较奥沙利铂(L-OHP)和5-氟尿嘧啶(5-FU)手术前保留灌肠对直肠癌增殖细胞抗原(PCNA)表达的影响,为直肠癌的灌肠化疗提供理论依据。方法选择2000年10月～2003年8月我院收治的直肠癌患者70例,随机分成奥沙利铂组(30例)、5-FU组(30例)、对照组(10例),术前每晚分别灌入奥沙利铂(50mg)、5-FU(500mg)、生理盐水各20ml,行保留灌肠,连续7天。分别于治疗前1天、第8天钳取癌灶粘膜送检,行PCNA免疫组化染色。结果奥沙利铂组与5-FU组治疗后其PCNA阳性细胞数均明显减少(P<0.01),且奥沙利铂组治疗后其PCNA阳性细胞数减少较5-FU组更为明显(P<0.05)。结论奥沙利铂及5-FU保留灌肠均可抑制直肠癌细胞增殖,且奥沙利铂作用较5-FU更显著,奥沙利铂手术前保留灌肠可作为直肠癌术前辅助治疗方案。
Objective To study the Influence on the expression of proliferation cell nuclear antigen (PCNA)in rectal carcinoma through retention-enema with L-OHP and 5-FU.Methods 70 cases of rectal carcinomas were randomized Into three groups:the L-OHP group(30 cases),the 5-FU group(30 cases) and normal control group(10 cases),treated with L-OHP(50mg),5-FU(500mg)and normal saline (20ml)every night through retention-enema separately for serven days.Mucosa of rectal carcinoma were sampled and PLNA protein were simultaneously detected by immunohistochemical method on the first and eighth day.Result The expression of PCNA was significantly decreased In both L-OHP group and 5-FU group alter treatment(P<0.01),foe decrease In L-OHP group was more obvious than that In 5-FU group(P<0.05), and the Change In normal control group was of no significanc(eP>0.1).Conclusion Foe cell proliferation of rectal carcinoma could be inhibited by L-OHP and 5-FU through retention-enema.The effects of L-OHP was more obvious than that of 5-FU In the same concentration.So the treating method through retention-enema with L-OHP should be used as a routine therapeutic scheme before operation.
出处
《国际医药卫生导报》
2005年第6期14-15,共2页
International Medicine and Health Guidance News
关键词
奥沙利铂
直肠癌
局部化疗
治疗性灌肠
L-OHP rectal carcinoma local chemotherapy therapeutic enema
