摘要
目的 探讨甲状腺微小乳头状癌的临床病理特点。方法 常规病理检查 4 0 0例经手术切除的甲状腺良性疾病标本 ,筛选出微小癌病例 ,应用光镜观察其形态改变 ,并用SP法检测甲状腺球蛋白 (Tg)、细胞角蛋白 (CK 34βE12 )、上皮膜抗原 (EMA)的表达特点。 结果 4 0 0例中共检出微小乳头状癌 19例 ,检出率为 4 8%。具有诊断意义的主要组织学特征为毛玻璃状 (透明 )细胞核 ;核内假包涵体 ;核沟 ;纤维性间质反应或砂砾体。免疫组化标记 17例高分子质量细胞角蛋白、16例上皮膜抗原、19例甲状腺球蛋白均呈 (+)。结论 甲状腺微小乳头状癌为乳头状癌变型的特殊表现。高分子质量角蛋白和上皮膜抗原表达强阳性对于诊断具有较高的特异性。
Objective To study the clinical and pathological featueres of thyroid papillany micro carcinoma. Methods 400 cases of thyroid benign samples were examined by routine and continuous section of pathological examination. The microcarcinoma samples were selected and clinical changes were observed. Thyroid globin (Tg), cytokertin (Ck/34 β E12), and epithelial membrane antigen (EMA) were detected With SP method. Results In 400 postoperative benign thyroid samples, 19 cases of thyroid papillary micro carcinoma were found, and the detected rate was 4.8%. The main histopathologic features were hylaline degeneration, nuclear pseudoinclusion, nuclear groove, fibrous stromal reactions to psammomatous body. Imnunohistochemical staining showed that 17 cases were positive for light molecular CK/34 β E12, 16 cases were positive for EMA. 19 cases were positive for Tg. Conclusion Thyroid papillary microcarcinoma is a special presentation of thyroid papillary carcinoma subtype. The strong positive for high molecular CK/34 β E12 and EMA is highly specific for diagnosis of thyrid papillary microcarcinoma.
出处
《诊断病理学杂志》
CSCD
2004年第5期326-327,I086,共3页
Chinese Journal of Diagnostic Pathology
基金
广东省科委科技重点攻关项目 [1998(178) ]
