摘要
目的研究影响肝门部胆管癌预后的因素.方法回顾分析本院自1997年12月～2002年12月收治的200例肝门部胆管癌的临床资料,进行统计学分析.结果200例患者中以黄疸(94.4%)、瘙痒(57.8%)和腹痛(33.0%)为主要症状.获得手术切除126例,手术切除率为63%,根治性切除65例,姑息切除61例,剖腹探查21例,姑息性内外引流53例.统计学处理结果显示术后生存时间与术前血清总胆红素水平、手术方式及AJCC TNM分期三个因素显著相关,与年龄、合并胆石与否、Bismuth-Corlette分型、血管(门静脉或肝动脉)侵犯、肿瘤细胞分级、术后放疗与否和术后化疗与否无显著相关.结论早期诊断和根治切除是改善肝门部胆管癌疗效的重要措施.
Objective To explore the prognosis factors of hila r cholangiocarcinoma. Methods A retrospective clinical analysis was made in 200 patie nts with hilar cholangiocarcinoma,who were treated in our hospital from December 1997 to December 2002. Results There were 118 males and 82 females in 200 patients wit h a ratio of male vs female 1.44∶1. The age ranged from 26 to 81 years old with a mean of 55.8. Jaundice (94.5%), pruritus (57.7%) and abdominal pain (33. 0%) were the present main symptoms. Tumor resection was performed on 126 cases , with a resection rate of 63% including radical resection 65 cases and palliati ve resection 61 cases. Twenty one cases underwent paunched exploration. Fifty th ree cases were treated by palliative internal or external drainage.The statistic al analysis showed that preoperative tatal serum bilirubin level, surgical proce dure and AJCC TNM stage affected postoperative survival significantly, but age, choledocholithiasis,Bismuth-Corlette type,vascular(including portal vein and he patic artery) invasion, histopathological type and grade, postoperative radiothe rapy and postoperative chemotherapy were not significant prognostic factors. Conclusion Early dignosis and radical resection are important m easures to improve the prognosis of hilar cholangiocarcinoma.
出处
《肿瘤》
CAS
CSCD
北大核心
2005年第2期166-169,共4页
Tumor
关键词
胆管癌/外科学
预后
因素分析
统计学
Cholangiocarcinoma/surgery
Prognosis
Factor analy sis,statistical
