摘要
①目的 探讨无精子症病人的细胞遗传学效应。②方法 采用外周血培养方法对57 例原发性无精子症病人进行染色体核型分析。③结果 检出染色体核型异常病人23 例,均涉及性染色体。最多的为47,XXY17例,检出率为29.83%,占异常核型的73.91%。其次为大Y染色体4 例,检出率为7.02%,占异常核型的7.39%。46,XY/47,XXY和47,XYY各1例,检出率为1.75%,占异常核型的4.35%。④结论 性染色体异常是原发性无精子症发生的根本原因之一。
Objective To study the cytogenetical effect of the patients with azoospermia. Methods Using the technique of peripheral blood culture, the chromosome karyotype of 57 patients with azoospermia was analyzed. Results Abnormal chromosome karyotype(ACK) was detected in 23 patients, sex chromosomes were involved in all these cases, the most were 47,XXY, 17 cases, which accounted for 29.83% of patients studied and 73.91% of those with ACK ; then were big Y chromosome, four cases, accounting for 7.02% of patients studied and 17.39% of those with ACK: 46,XY/47,XXY and 47,XXY, one case for each type. Conclusion The sex chromosome abnormality is one of the major causes of primary azoospermia.
出处
《齐鲁医学杂志》
2005年第1期33-34,36,共3页
Medical Journal of Qilu
关键词
少精液症
性染色体
染色体显带
oligospermia
sex chromosomes
chromosome banding
