关于基质金属蛋白酶9(MMP-9)的最新进展被引量：23

Recent adavance of matrix metalloproteinase 9

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摘要基质金属蛋白酶9(MMP-9)是人体内最重要的蛋白酶之一,属于基质金属蛋白酶超家族成员中明胶酶的一种,又称明胶酶B。其主要功能是分解细胞外基质,参与人体许多生理及病理过程。该因子在人体内很多细胞中,包括在破骨细胞中都能表达,其表达又受到体内众多因子的调节,如细胞生长因子,激素,基质金属蛋白酶组织抑制剂(TIMPs)等。其作用底物主要是Ⅳ、Ⅴ、Ⅶ、Ⅹ型胶原,明胶及弹性纤维。 Matrix metalloproteinase 9 is one of the most important proteinases in vivo.It belongs to the gelatinases of the matrix metalloproteinase hyperfamily.Its main function is to decompose extracellular matrix,participate in many physiological and pathological processes.Many kinds of cells including the osteoclasts can express matrix metalloproteinase 9 and its expression is adjusted by many factors,for example:cell growth factor,hormone,TIMPs etc.Its main operational project is Ⅳ,Ⅴ,Ⅶ,Ⅹcollagen,gelatin and elastic fibers. [

作者刘加强杨富生

机构地区第四军医大学口腔医学院

出处《牙体牙髓牙周病学杂志》 CAS 2005年第3期168-171,共4页 Chinese Journal of Conservative Dentistry

关键词基质金属蛋白酶9 明胶酶琏质金属蛋白酶组织抑制剂 Matrix metalloproteinase-9 gelatinase TIMPs

分类号 R780.2 [医药卫生—口腔医学]

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