摘要
目的:探讨葛根素注射液对急性脑缺血模型大鼠脑细胞损伤的保护作用。方法:采用闭夹大脑中动脉造成局部脑缺血模型,对实验标本作HE染色后观察其脑组织的病理学改变。结果:葛根素干预组死亡神经元数明显少于单纯缺血组(P<0.05),同时脑水肿程度明显较轻。结论:葛根素对大鼠急性脑缺血损伤有保护作用。
Objective: To study the protection of puerarin on the cerebral injury in the rats with acute local ischemia. Method: Rat model of acute local cerebral ischemia was made by ligating middle cerebral artery. The cerebral damage was evaluated by staining with hematoxylin and eosin((HE). Result: The number of died neurons were significantly less in puerarin-treated rats than in the rats with cerebral ischemia (P<0. 05). Similarly,the cerebral edema were significantly attenuated in the puerarin-treated rats as compared with cerebrally ischemic rats. Conclusion: Puerarin can prevent the neuron from damage induced by acute cerebral ischemia.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第6期457-459,共3页
China Journal of Chinese Materia Medica
基金
广西壮族自治区卫生厅医药卫生科研课题(Z2001072)
