摘要
用含11％花生油、茶油、牛油的饲料分别饲养SD大鼠，观察其血清和心、肝、脑丙二醛（MDA）、血清和肝超氧化物歧化酶（SOD）水平、生物膜磷脂脂肪酸组成及膜流动性的改变。结果发现：花生油组心线粒体及牛油组RBC膜磷脂脂肪酸含量与摄入脂肪酸呈正相关（r分别为0.6275和0.6967，P＜0.01）。喂饲花生油引起生物膜磷脂多不饱和脂肪酸含量增加，膜流动性增高，血清和肝SOD水平较低（分别为3.76±1.61mg／L、616±163μg／g），血清MDA较高（8.70±1.71μmol／L），提示脂质过氧化程度较高。喂饲茶油引起膜磷脂单不饱和脂肪酸含量增加，膜流动性和血清SOD（5.66±2.00mg／L）较高，血清及脑MDA较低（5.92±1.15μmol／L，2.45±0.44μmol／g），提示脂质过氧化程度较低。喂饲牛油引起膜磷脂饱和脂肪酸含量增加，膜流动性较低，血清及肝SOD较高（5.79±0.56mg／L，886±99μg／g），血清MDA较低（7.04±1.66μmol／L），脑MDA较高（3.96±1.68μmol／g），脂质过氧化程度介于花生油组与茶油组之间。
3 groups of SD rats were fed with diets containing 11% peanut oil,tea-seed oil or beef tallow respectively.The results showed that peanut oil feeding induced an increase in polyunsaturated fatty acids in the biological membrane phospholipid,biological membrane fluidity and serum malondialdehyde (MDA,8.70±1.71μmol/L ) and a decrease in serum and liver SOD (3.76±1.61mg/L,616±163μg/g).Tea-seed oil feeding induced an increase in monounsaturated fatty acids in the biological membrane phospholipid,membrane fluidity and serum SOD (5.66±2.00mg/L )and a decrease in serum and brain MDA (5.92±1.15μmol/L,2.45±0.44μmol/g).Beef tallow feeding induced an increase in saturated fatty acids in the biological membrane phospholipid,serum and liver SOD (5.79±0.56mg/L,886±99μg/g),brain MDA(3.96±1.68μmol/g) and a decrease in membrane fluidity and serum MDA (7.04±1.66μmol/L).There were positive correlations between heart mitochondria phospholipid fatty acid contents and dietary fatty acids in the peanut oil group (r=0.6275,P＜0.01),RBC membrane phospholipid fatty acid contents and dietary fatty acids in the beef tallow group (r=0.6967,P＜0.01.
出处
《卫生研究》
CAS
CSCD
北大核心
1994年第3期153-156,共4页
Journal of Hygiene Research
基金
国家自然科学基金
关键词
食用油
生物膜
磷脂
过氧化脂质
Edible oil
lipid peroxidation
biological membrane phospholipid
fatty acids
biological membrane fluidity
