摘要
体外循环所致的炎症反应与术后肺损伤密切相关。其中中性粒细胞在肺内蓦集,释放蛋白酶、氧自由基等毒性物质是一重要发病机制。乌司他丁为广谱丝氨酸蛋白酶抑制剂,可同时抑制胰蛋白酶、组织蛋白酶、弹性蛋白酶等多种水解酶的活性,以及体外循环所致的多种炎症介质的释放,可防治体外循环术后肺损伤。
There is a close relationship between lung injury after cardiopulmonary bypass and inflammatory responses.Among various inflammatory mediators neutrophil is thought to be a major pathogenesis by accumulation in distal airway and secreting elastase and oxygen-free radicals.Ulinastatin,a serine protease inhibitor,can inhibit the activities of trypsin,cathepsin,elastase,et al.This makes it probable that ulinastatin is suitable for protection against and therapy for lung injury after cardiopulmonary bypass.
出处
《心血管病学进展》
CAS
2005年第2期160-163,共4页
Advances in Cardiovascular Diseases
