摘要
为了从分子水平探讨硒与汞的拮抗效应和不同形态汞对脑的损伤 ,应用RT PCR方法和免疫组织化学方法研究了大鼠在汞污染粮食诱导下脑中c- fosmRNA表达和c -FOS蛋白表达 .结果表明 ,汞污染粮食能够显著诱导大鼠脑c -fosmRNA表达和c -FOS蛋白表达 ;硒能够拮抗汞在脑中的蓄积水平 ;硒能够拮抗汞诱导c- fos表达 .同时分析了硒汞拮抗的分子机制 .
The objective of this paper is to study the antagonisms between selenium and mercury and the effect of different species mercury on the brain injury. The expression of c-fos mRNA and c-FOS protein in rat brain induced by Hg-contaminated rice was observed by using reverse transcriptions polymerase chain reaction (RT-PCR) and immunocytochemical methods. The results show the Hg-contaminated rice induced significantly the expression of c-fos mRNA and c-FOS protein; selenium could antagonize mercury accumulative level in brain. Antagonistic effects of selenium on the expression of c-fos included by mercury and the molecule mechanism of the antagonisms between selenium and mercury was probed, too.
出处
《环境科学》
EI
CAS
CSCD
北大核心
2005年第2期163-166,共4页
Environmental Science
基金
国家自然科学基金资助项目 (2 0 1770 13 )
中国科学院知识创新工程 (KZCX3 SW 43 7)
关键词
硒
汞
拮抗效应
C-FOS
selenium
mercury
antagonistic effects
c-fos
