摘要
调查１５７名在燃煤型地氟病区出生和长大的１２～１３岁儿童，并作动物高氟摄入实验。结果发现：从童年早期开始的长期高氟摄入会引起儿童脑力工作能力降低；长期摄入高氟的儿童发锌含量下降。多元相关分析表明，儿童脑力工作能力与发锌呈正相关。同时，长期高氟摄入的动物脑中５—羟吲哚乙酸降低和去甲肾上腺素增高，这可能是使儿童脑力工作能力降低的作用机理，需进一步实验证实。
We made an investigation in 157 chil- dren,aged 12 13 ,born and grew up in a coal burn-ing pattern endemic fluorosis area and an experimenton excessive fluoride intak in rat.The resultsshowed:(1)Excessive fluoride intake since early child-bood would reduce mental work capacity(MWC) andhair zinc content;(2)The effect on zinc metabolism was a mechanism of influence on MWC by excessivefluoride intake ;(3)Excessive fluoried intake de-creased 5-hydroxy indole acetic acid and increasednorepinephrine in rat brain;whether this is also amechanism of the influence on MWC awaits awaits confirma-tion.
出处
《华西医科大学学报》
CSCD
1994年第2期188-191,共4页
Journal of West China University of Medical Sciences
关键词
氟中毒
脑力工作能力
毛发
锌
儿童
Children Fluorosis Mental work capacity Hair zinc 5-hydroxy ndole acetic acid Norepinephrine
