摘要
刺乌头碱(0.5mg·kg^(-1))对3-乙酰乌头碱(0.07mg·kg^(-1))诱发大鼠心律失常有显著的对抗作用.二者伍用(剂量LA:AA=7:1)对镇痛作用无明显影响.但刺乌头碱可显著提高3-乙酰乌头碱小鼠的LD_(50),从而提高其治疗指数.扩大其安全范围。
Lappaconitine (LA) 0. 5 mg· kg-1had significant antagonistic action on the ar-rythmia induced by 3-acetylaconitine ( AA ) 0.07 mg·kg-1in rat. When LA and AA were used in combination (7:1) in mice, the analgesic activity of AA was not influenced marked-
ly by LA but the LD50 of AA was increased by 50% ,therefore the therapeutic index of AA was increased and the margin of safety was widened.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1993年第5期382-385,共4页
Chinese Pharmacological Bulletin
关键词
刺乌头碱
3-乙酰乌头碱
心律失常
止痛
lappaconitine
3- acetylaconitine
arrythmia
toxicity
analgesia
