摘要
目的明确黄腐酸钠是否对大鼠重症胰腺炎胰腺微循环紊乱有防治效果。方法采用胰腺被膜下注射5%牛磺胆酸钠液制备大鼠重症胰腺炎模型。结果除正常组外,各组胰腺组织光镜病变程度随观察时间延长呈加重趋势,模型组胰腺病变程度明显重于同期黄腐酸钠治疗组(P<0.05)。空肠微循环改变结果近似上述胰腺微循环变化。黄腐酸钠治疗组同期血浆内皮素水平显著低于模型组(P<0.05)。上述结果提示各组胰腺微血流改变与其胰组织病理改变、血浆内皮素水平变化有相关性。结论①黄腐酸钠可明显改善重症胰腺炎微循环,并有控制病情发展的作用。②血浆内皮素变化是作为观察重症胰腺炎病变预后的客观指标之一。
Objective To study the effect of sodium fulvate on prevention and treatment of micro- circulation disorder of pancreas.Method A rat severe pancreatitis model was used.Result Compared with rats of the control model group,histopathologie changes in pancreas of rats in the treatment group were significantly alleviated(P<0.05).The mierocirculation value of the tail of pancreas was remarkably higher in the treatment group than that in either the parallel control model group or the group treated with dextran(P<0.05).The plasma level of endothelin was evidently lower in the sodium fulvate treated group than that in the control model group(P<0.05).Conclusion ①Sodium fulvate can significantly improve pancreatic microcirculation in severe pancreatitis and limits progress of the later;②Change in plas- ma level of endothelin is one of objective indexes for predicting prognosis of severe pancreatitis.
出处
《中华肝胆外科杂志》
CAS
CSCD
1998年第2期95-98,共4页
Chinese Journal of Hepatobiliary Surgery
