摘要
每天给予大鼠ip MnCl_2·4H_2O15mg/kg共84天,引起大鼠肝细胞线粒体锰、铜和锌含量升高,微粒体铜含量升高、铁和锌含量下降。结果提示:肝线粒体为锰蓄积部位之一,而微粒体无明显锰蓄积,染锰引起肝细胞线粒体和微粒体微量元素含量的改变可能在锰的生化毒性方面有重要意义。
The trace element levels of hepatic mitochondria and microsome in rats were changed by the administration of ip MnCl_2·4H_2O 15 mg/kg·d for 84 days. It showed that the hepatic mitochondrial manganese, copper and zinc levels increased significantly and the microsomal copper level also significantly increased, while their ferrum and zinc levels significantly decrease. These results suggested that manganese could be accumulated in hepatic mitoehondria but not in hepatic microsomes. The changes of trace element level in hepatic mitochondria and microsomes might play an im potantr role in manganese biochemical toxiciles
出处
《职业医学》
1993年第3期139-141,共3页
China Occupational Medicine
关键词
锰
微量元素
线粒体
微粒体
manganese,trace element,mitochondrion,microsome
