摘要
朊病毒(Proteinaceous Infectious Particales简称Prions)病是一种人和动物共患的亚急性海绵状脑病,其病原是一种具有传染性的不含核酸的病原体,故称为感染性朊病毒蛋白(PrP)。但它是如何复制成为异常PrPSc,并沉积在脑组织而引起发病,目前还是生物医学的一大课题,也是指引我们寻找治疗方案的思路。本文就朊病毒的历史背景、发病机制与症状等研究进展进行了综述,并就其预防措施及治疗方案提出了新的思路。
Prions, generally called Proteinaceous Infectious Particales (PrP), are manifest as one kind of subacutely spongiform encephalopathies in human and animals, whose pathogens are infective protein without nucleic acids. However, the way PrPc duplicate into misfolding PrPSc and cause brain - destroying diseases remains to be one of the most intricate tasks. The article dwells on the background、pathogenesis and etiology to advance an new sight on early diagnosis and therapy of the Prions.
出处
《中山大学研究生学刊（自然科学与医学版）》
2003年第4期20-29,共10页
Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)
