摘要
背景:孤独症是一种神经生物学疾病,患者血液中5-羟色胺浓度升高被认为是该症生物学研究中最确凿的和重复性最好的研究结果之一,出生季节和母孕期母亲的情绪是否也与孤独症的发生有关?目的:比较孤独症儿童和正常儿童血浆5-羟色胺浓度、出生季节和孕期母亲情绪的差异,探讨孤独症5-羟色胺增高的原因。设计:以患儿和正常儿童为研究对象的观察对比研究。单位:一所大学医院临床心理组,湘雅二院精神卫生研究所,一所市级聋儿康复中心。对象:孤独症组(n=54)来自中南大学湘雅二院精神卫生研究所儿童门诊和深圳市特教学校的孤独症训练班,符合DSM-IV孤独症诊断标准,儿童适应行为评定量表总分>40;正常儿童组(n=55)来自长沙市和深圳市为幼儿园及小学的儿童,经体格检查、神经系统检查、精神状况检查、发育水平粗查,未发现明显的躯体疾病、神经系统疾病及发育延迟者。方法:对孤独症儿童和正常儿童进行了血浆5-羟色胺检测、并调查出生季节、孕期母亲情绪;对孤独症儿童进行适应行为评定量表评定。主要观察指标:两组受试对象血浆5-羟色胺水平,出生季节和母孕期母亲情绪。结果:孤独症儿童适应行为评定量表的得分为67.65±1.67。孤独症儿童5-羟色胺浓度犤(0.78±0.32)μmol/L犦高于正常儿童犤(0.62±0.16)μmol/L犦,差异有显?
BACKGROUND:Autism is a kind of neurobiological disease.The increase of plasma concentration of 5 hydroxytryptamine(5 HT) is considered to be one of study results,which is the most definite and has the best repetition,for the biological investigation of autism. Whether the season of birth and maternal mood during pregnancy are correlated with the occurrence of autism? OBJECTIVE:To compare the differences of the plasma concentration of 5 HT,season of birth and the maternal mood during pregnancy between autistic and normal children,and probe into the cause of increased 5 HT in autism. DESIGN:An observational comparative study taking autistic and normal children as the subjects. SETTINGS:A clinical psychological department of a university hospital;Mental Health Institute of the Xiangya Second Hospital;A rehabilitation center for dumb children of city grade.PARTICIPANTS:Children in the autistic group(n=54),who were in accordance with the diagnostic criteria of autism in Diagnostic and Statistical Manual of Mental Disorders Fourth Edition(DSM IV) and had the total score of social adaptive ability scale(SAAS) over 40, were selected from the Outpatient Clinic for Children of the Mental Health Institute,Xiangya Second Hospital of Central South University and the training class of autism of Shenzhen Special Education School;Children in the normal control group,who had no obvious somatic and neurological diseases,and developing delay detected by physical,neurological and mental status examinations,rough detection of developing level,were selected from the primary school and kindergarten in Changsha and Shenzhen cities. INTERVENTIONS:The plasma level of 5 HT was examined, season of birth and maternal mood during pregnancy were investigated in autistic and normal children.The children with autism were accessed with SAAS. MAIN OUTCOME MEASURES:The plasma level of 5 HT,the season of birth and the maternal mood during pregnancy in both groups. RESULTS:The score of SAAS in children with autism was 67.65±1.67.The plasma level of 5 HT was(0.78±0.32) μmol/L in the autistic group,which was significantly higher than that in the normal control group [(0.62±0.16) μmol/L](t=3.17,P=0.002). There were 17 children with autism had increased 5 HT.Compare with normal children,most children with autism were born in winter and spring,and their mother had obvious mood problems during pregnancy. CONCLUSION:The 5 HT level is higher in children with autism than in normal children.Most children with autism were born in winter and spring,and their mother had obvious emotional problems during pregnancy.There are phase of high functioning of 5 HT in mother in key period of fetus cerebra development that may be one of the causes of hyperserotonemia in autism,and that is possibly one of the etiologies of autism.
出处
《中国临床康复》
CSCD
北大核心
2005年第4期218-220,共3页
Chinese Journal of Clinical Rehabilitation
