摘要
目的:观察急性胰腺炎病人细胞免疫功能、血清中细胞因子的变化,探讨他们在急性胰腺炎发病机理中的作用。方法:采用流式细胞仪,测定急性胰腺炎病人T淋巴细胞亚群,采用酶联免疫吸附实验测定急性胰腺炎病人血清中IL-2、IL-8。结果:T淋巴细胞亚群中CD4阳性细胞百分比和CD4/CD8比值在急性胰腺炎病人中降低,IL-2、在惠性胰腺炎病人中降低、IL -8在急性胰腺炎病人中增高。结论:急性胰腺炎症过程中存在细胞免疫功能低下,且有多种细胞因子参与其发病机理,某些细胞因子的升高与疾病的严重程度相关。
Objective: To determine the cellular immunity function and the serum cytokine, and investigate the their roles in the pathogenesis of patients with acute pancreatitis. Methods: The levels of CD4T lymphocyte and CD8 T lymphocyte were determined by flow cytometry, and the levels of serum interleukin -2 and interleukin-8 were determined by ELASA in patients with acute pancreatitis. Results: The CD4positive cell, CD4/CD8ratio and interleukin -2 were reduced in patients with acute pancreatitis, while the interleukin - 8 was increased in patients with acute pancreatitis. Conclusion: The cellular immunity function are damaged in patients with acute pancreatitis, and the cytokine may play an important role in the pathogenesis of acute pancreatitis, and their release is also closely related to the severity of acute pancreatitis.
出处
《黑龙江医药科学》
2005年第1期37-38,共2页
Heilongjiang Medicine and Pharmacy
