摘要
目的验证不同工艺制备的降酶灵胶囊中五味子总木脂素的溶解度和溶出速度。方法以聚乙烯吡咯烷酮 (PVP) 为载体制备固体分散体; 以β -环糊精 (β- CD) 包合技术制备包合物, 以人工胃液为溶出介质, 紫外分光光度法测定不同制备工艺下成品的溶解度和体外溶出度。结果固体分散体的五味子总木脂素溶解度最大,与原工艺相比溶出度显著增加 (P<0. 01)。结论固体分散体有速释作用, 可考虑用固体分散技术改进降酶灵胶囊的制备工艺。
Objective To test and verify the solubility and dissolution of total Lignans in jiangmeiling capsules prepared with different technics.Methods Jiangmeiling sample was prepared by PVP solid disperson or β-CD complexation,and solubility.Dissolution characteristics of finished products produced with different technology were determined by UV spectrophotometry.Results Comparing with conventional process and β-CD complexation,the total Lignans in PVP solid dissolve quickly and completely.Conclusion Solid dispersion is able to release rapidly as an ameliorated technic.
出处
《福建医药杂志》
CAS
2005年第1期95-97,共3页
Fujian Medical Journal
基金
福建省科技厅青年科技人才资助项目 (项目编号2004J045)
