摘要
凝血酶不仅在凝血过程中起主导作用,还可以引发多种凝血酶受体介导的分子和细胞间相互作用,在动脉粥样硬化和再狭窄形成中起着重要的作用。现就凝血酶及其受体的特性,以及对血管内皮细胞的作用,包括通透性改变、内皮生长因子、基质金属蛋白酶、黏附分子表达作一综述。
Thrombin plays an important role in blood coagulation. Thrombin also exerts direct effects onvascular cells, which interacts with members of the protease-activated receptor family. Evidences implicate thrombin-mediated signaling events in the response to injury that typifies vascular lesion formation in atherosclerosis andrestenosis. In this review, we focus on that thrombin signaling in the endothelium is linked to multiple changes,including alterations in permeability, expression of matrix metalloproteinases, vascular endothelial growth factor andadhesion molecules.
出处
《细胞生物学杂志》
CSCD
2005年第1期57-60,共4页
Chinese Journal of Cell Biology
基金
山东省自然科学基金资助项目(No.Y2003C01)~~
