摘要
目的探讨葡萄胎差异表达新基因F10在不同类型滋养细胞肿瘤中的表达及其与恶性滋养细胞肿瘤侵袭的关系。方法采用原位杂交方法检测12例葡萄胎、6例侵袭性葡萄胎、8例绒癌中F10表达情况。结果F10在全部葡萄胎、侵袭性葡萄胎、绒癌中均呈阳性表达,其在葡萄胎、侵袭性葡萄胎、绒癌中的表达强度递增,有显著性差异(P<0.001)。结论F10可能与滋养细胞肿瘤的发生及其侵袭行为相关,在侵袭或滋养细胞恶变中起一定作用。
Objective To study the expressions of the novel gene F10 associated with hydatidiform mole in different trophoblastic tumors and explore the relation of F10 expression with the invasiveness of malignant trophoblastic tumor. Methods In situ hybridization was used to study the expression of F10 in 12 cases of hydatidiform mole, 6 cases of invasive mole, and 8 cases of choriocarcinoma. Results F10 mRNA was positive in all cases of hydatidiform mole, invasive mole, and choriocarcinoma, and the expression intensity significantly increased in the order of hydatidiform mole, invasive mole and choriocarcinoma (P<0.001). Conclusion The expression of F10 gene may relate to the occurrence and invasiveness of trophoblastic tumor, with possible involvement in the invasion or malignant changes of trophoblastic cells.
出处
《第一军医大学学报》
CSCD
北大核心
2005年第2期171-173,共3页
Journal of First Military Medical University
基金
973国家重点基础研究发展规划资助项目(G1999055903)~~
关键词
葡萄胎
绒毛膜癌
滋养层肿瘤
基因表达
原位杂交
hydatidiform mole
choriocarcinoma
trophoblastic neoplasms
gene expression
in situ hybridization
