摘要
目的 :综合分析人体内二氯二苯二氯乙烯 (DDE)含量与女性乳腺癌的关系。方法 :运用Meta分析方法 ,综合 10篇DDE与人类乳腺癌关系的病例对照研究报告 ,分析DDE含量在病例及对照组间的差异以及DDE含量与乳腺癌的剂量效应关系。结果 :病例与对照两组对象体内DDE总标化差ds=0 12 2 8,校正ds95 %可信区间为 (- 1 0 5 14～ 1 2 970 ) ;DDE与乳腺癌患病风险的趋势 1 0 17,OR 95 %可信区间为 (- 1 0 5 14～ 1 2 970 ) ;开展研究的国家、DDE的生物材料来源以及对照组的选择均影响文献的同质性。结论 :DDE与乳腺癌的关系尚需流行病学研究进一步验证 ;在大量使用该有机氯农药的地区 ,DDE可能是乳腺癌的危险因子 ;在进行相关研究时 ,应选择血浆作为DDE暴露测量的生物材料。
Objective:To polysynthetic analyze the relationship between DDE level and breast cancer.Methods:10 reports of case-control studies about relationship between DDE and human breast cancer were collected. Meta analyses method was used to analyze the difference between case teams and control teams and the dose-responding correlation between DDE contains and breast cancer.Results:The total standardized difference (d s) between case teams and control teams is 0.1228, and 95% C.I. is from -1.0514 to 1.2970. The adjusted total trend OR between DDE and breast cancer is 1.017, and 95% C.I. is from -1.0514 to 1.2970. The countries being researched, biomaterials of DDE and objects of control teams influence homogeneity of reporting files.Conclusion:The relationship between DDE and breast cancer should be explored through further epidemiological study in the future. However DDE may be a risk factor for breast cancer in areas where organochlorine pesticides had ever been sprayed widely. Serum sample is the reliable biomaterial for measuring exposure level of DDE.
出处
《现代预防医学》
CAS
北大核心
2005年第2期91-93,110,共4页
Modern Preventive Medicine
基金
国家自然基金重点项目 (3 0 0 3 0 12 0 )
