摘要
目的了解临床患者分离的鲍氏不动杆菌对11种抗菌药物的耐药性,探讨其变化规律,为有效控制感染和临床治疗提供依据。方法按照美国临床实验室标准化委员会(NCCLS)推荐的方法和规则,采用浓度梯度法(Etest)测定并比较亚胺培南等11种抗菌药物对鲍氏不动杆菌的体外抗菌活性。结果11种抗菌药物中亚胺培南抗菌活性最高,其次为头孢哌酮/舒巴坦和阿米卡星,耐药率分别为1%、4%和4%;头孢他啶、哌拉西林/他唑巴坦、环丙沙星、庆大霉素、头孢吡肟、替卡西林/克拉维酸的抗菌活性也较高,耐药率分别为18%、12%、14%、20%、12%和12%;头孢曲松和头孢噻肟的抗菌活性低,中介耐药率分别为71%和67%;在监测的100株鲍氏不动杆菌中,多重耐药菌株(耐≥3种抗菌药物)占15%,对>5种抗菌药物的耐药菌株占867%,>8种抗菌药物的耐药菌株占467%,未发现针对11种抗菌药物全部耐药的菌株。结论鲍氏不动杆菌对抗菌药物已产生明显多重耐药性,应警惕并重视该菌感染及耐药性监测,预防医院感染的发生。
OBJECTIVE To study the drug resistant of Acinetobacter baumannii from clinics to 11 antibiotics ~and explore the mutative rule to prevent infection effectively and provide the evidence to clinical treatment. ~METHODS According to NCCLS, E-test was used to judge antimicrobial activity of A. baumannii in vitro to 11 antibiotics, and contrast with them such as imipenem. RESULTS The antibacterial activity in vitro of Imipenem was the highest, the next uare cefoperazohe/sulbactam, amikacin, theiv resistanol rate was 1%, 4% and 4%, respectively. The antibacterial activity in vitro of ceftazidime and ceftriaxone was the lowest, their intermediate resistane rate was 71% and 67%. In 100 studied strains of A. baumannii, multi-resistant bacteria accounted for 15% (≥3 kinds antibiotics); 86.7% (≥5 kinds); 46.7% (≥8 kinds) respectively. We didn′t find pan-resistant strains to 11 antibiotics. CONCLUSIONS A. baumannii strains isolated from clinical patients show distinct ~multiple antibacterial resistance. We must keep an eye out for A. baumannii infection and its drug-resistant change in orde to prevent the appearance of nosocomial infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2005年第1期112-114,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
耐药性
药物敏感试验
Acinetobacter baumannii
Drug resistance
Drug sensitive test
