摘要
目的 探讨老年人血尿酸水平与颈动脉粥样硬化程度的相关性。方法 应用高频多普勒超声检测老年患者的颈动脉内膜中层厚度(IMT)及斑块程度,测定血尿酸、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖、肌酐、24h尿白蛋白。分析血尿酸与颈动脉IMT及斑块的关系。结果 血尿酸四分位组分析显示,随分位数增加,老年人颈动脉IMT及斑块严重程度增加。血尿酸与颈动脉IMT的相关性独立于年龄、性别、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、肌酐,血尿酸与斑块严重程度的相关性独立于年龄、性别、患有原发性高血压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、肌酐、空腹血糖及24h尿白蛋白的自然对数。结论 老年人血尿酸水平与颈动脉IMT正相关,血尿酸升高是颈动脉斑块的危险因素,独立于年龄、性别、患有原发性高血压病、血脂、血肌酐等心血管危险因素和肾损伤指标。
Objective To investigate correlation between serum level of uric acid (SUA) and carotid atherosclerosis in the elderly. Methods A group of 113 elder subjects were examined by high-frequency Doppler ultrasound to measure their intima-media thickness (IMT) of carotid artery and severity of atherosclerotic plaque formation. Blood levels of biochemical factors such as SUA, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood sugar (FBS), creatinine (Cr) were determined, as well as 24h urine level of albumin (UALB). Correlation between SUA, IMT and the plaque was analyzed.Results SUA in quartile positively correlated with increasing IMT and severity of plaque in the elderly. SUA correlated with IMT of carotid artery, independent from age, gender, TC, TG, HDL-C, LDL-C and Cr, and correlated with severity of plaque adjusted for age, gender, history of hypertension, TC, TG, HDL-C, LDL-C, Cr, FBS and logarithm of UALB.Conclusions Level of SUA positively correlated with IMT, and increased level of SUA was a risk factor for carotid plaque, independent from other cardiovascular risk factors and renal impairment indicators, such as age, gender, history of hypertension,blood lipid level, Cr, etc.
出处
《中华全科医师杂志》
2005年第1期13-16,共4页
Chinese Journal of General Practitioners
