摘要
目的 研究薄荷醇和氮酮单独使用及合用时对水杨酸的促透作用。方法 采用离体鼠皮作透皮吸收试验。结果 薄荷醇对水杨酸的促透作用强于氮酮,而两药合用时的促透作用并不比分别使用时的促透效果好,在合用浓度较高时,甚至表现促透作用降低。
Aim Percutaneous penetration enhancement of 1 - menthol and azone on salicylic acid was studied. Methods Eaperimental solutions of 1 - menthol and azone, used singly and jointly, in different doses and hairless mouse skin were prepared. A percutaneous penetration apparatus and an ultraviolet spectrophotometer were employed to measure the absorption volume of salicylic acid. Results Percutaneous penetration enhancement of 1 - menthol was stronger than that of azone, but when they were used jointly, the action were not better or even lower, than that of 1 -menthol or azone used alone.
出处
《中国临床药理学与治疗学》
CAS
CSCD
1996年第1期26-28,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
薄荷醇
氮酮
水杨酸
促透作用
1 - menthol Azone Salicylic acid Percutaneous penetration enhancement
