摘要
目的:探讨长期服用茶多酚(greenteapolyphenols,GTP)对肝癌高危险人群T淋巴细胞亚群和NK细胞活性的影响。方法:以服用GTP和安慰剂满3年的1200名肝癌高危险人群为对象,采用SP一步染色法抽样检测淋巴细胞亚群、MTT法抽样检测NK细胞活性。结果:服用GTP人群的CD3、CD4、CD4/CD8及NK细胞活性均显著高于服用安慰剂的对照人群,P<005。CD8则明显低于对照人群,P<005。结论:长期服用GTP可影响肝癌高危险人群T淋巴细胞亚群和NK细胞活性,可能与预防人类肝癌的作用机制有关。
OBJECTIVE:To assess the effects of eong-term intaking (GTP) on T lymphocyte subgroups and NK cell activity among high risk change of population for liver cancer.METHODS:1 200 subjects with high risk for liver cancer were divided into two groups, one in taking GTP and the other a placebo. Then their T lymphocyte subgroups and NK cell activity were respectively sampled for tests by S-P one-step staining method and MTT method 。 RESULTS:The test group taking GTP had remarkably higher CD 3, CD 4, CD 4/CD 8 and NK cell activity than the control group taking a placebo (P<0.05) and CD 8 of the test group was obvious lower than the control group (P<0.05).CONCLUSIONS:The action of GTP to prevent human from liver cancer has a close link to immune regulation functions Chin J Cancer Prev Treat,2005,12(2):92-94
出处
《肿瘤防治杂志》
2005年第2期92-94,共3页
China Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(39869001)
广西自然科学基金(9912038)联合资助
关键词
茶多酚
淋巴细胞亚群
NK细胞活性
green tea polyphenols
T lymphocyte subgroups
natural killer cell activity
