摘要
目的:研究血清中血管内皮生长因子(VEGF)在早期宫颈癌诊断方面的价值.方法:以47例妇科良性肿瘤患者、16例宫颈炎患者及30例正常女性作对照,采用ELISA法测定了160例早期宫颈癌患者血清中VEGF的含量,其中144例早期宫颈癌患者做了术前、术后的对比测定.13例患者复发后测定VEGF值与术后VEGF值对比测定.结果:早期宫颈癌患者血清VEGF值显著高于妇科良性肿瘤、宫颈炎患者和健康女性(P均＜0.002),其诊断早期宫颈癌的敏感性为43.3%,特异性为96.7%,妇科良性肿瘤及宫颈炎的假阳性率分别为6.4%及12.5%;血清VEGF水平与肿瘤负荷相关,Ⅱ期宫颈癌及肿瘤直径＞4 cm的患者明显高于Ⅰ期宫颈癌及直径＜4 cm者,但与病理分级及淋巴结是否转移关系不大;术后绝大多数患者血清VEGF有一过性上升,明显高于术前,2个月～3个月后开始下降,低于术前水平;宫颈癌术后复发患者血清VEGF值呈上升趋势,与术后2个月的血清VEGF值比较,P＜0.05.结论:血清VEGF诊断早期宫颈癌的敏感性并不高,但对于鉴别宫颈炎与癌症,评价分期与宫颈癌体积的大小有一定的帮助.患者术后VEGF值曾一度降低,如再一次升高可能是复发的一个信号.
Objective: To evaluate the diagnostic value of serum VEGF in cervical cancer patients with stage Ⅰand Ⅱ. Methods: The levels of VEGF were detected in 160 cervical cancer patients with stage Ⅰand Ⅱ, and in 47 gynecologic benign tumor, 16 cervical inflammation, 30 healthy persons as control groups. Results: The serum levels of VEGF were significantly higher in cervical cancer than those in benign tumor, cervical inflammation and healthy control (P< 0.002). The sensitivity and specificity of diagnosis of cervical cancer were 43.3 % and 96.7 %. The false positive for benign tumor and cervical inflammation were 6.4 % and 12.5 %; The level of VEGF in cervical cancer was connected with the burden of cancer. The serum levels of VEGF were significantly higher in those patients with stage Ⅱand with tumor's diameter larger than 4cm than in those with stage Ⅰand with tumor's diameter small than 4 cm. The serum levels of VEGF were higher in most patients after operation, but lower after 2 or 3 months, lower than those before operation; The serum levels of VEGF were higher in those recurrent patients, higher than the serum levels after operation 2 or 3 months. Conclusion: Although the sensitivity of VEGF was not high enough, it might be helpful for differentiating the cervical inflammation with cancer, and predicting the stages and tumor size. If the serum levels were higher again after lower sometimes, it may be a sign of recurrence.
出处
《肿瘤研究与临床》
CAS
2004年第6期380-382,共3页
Cancer Research and Clinic
