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循环核酸对肺癌监测和患者功能预后的作用 被引量：2

Effect of circulating plasma nucleic acid on detection of lung cancer and patients'functional prognosis
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摘要 目的:循环核酸是指存在于血液(血浆或血清)中的细胞外游离DNA和RNA,恶性肿瘤患者血浆中循环核酸含量明显高于正常人,研究证实其来源于肿瘤细胞,并与原发肿瘤有着结构与功能上的某些一致性。探讨循环核酸对肿瘤诊断、治疗及其在肺癌患者功能预后中的价值。资料来源:应用计算机检索NCBIEntrezPubMed1980-01/2004-05相关循环核酸的文章,检索词“circulatingnucleicacidandlungcancer,并限定文章语言种类为英语。计算机检索万方数据库《中国临床康复》杂志1990-01/2004-05相关循环核酸的文章,限定文章语言种类为中文,检索词“循环核酸,肺癌,诊断”。资料选择:对资料进行初审,纳入标准:①循环核酸的组成、性质及其来源。②循环核酸在肿瘤诊断、治疗及其预后中的应用。③肺癌循环核酸研究的相关进展。开始查找全文,所查文献为RCT研究类文章,未排除是否盲法。资料提炼:共收集到67篇相关文献,含追溯法查找文献12篇。38篇文献符合纳入标准,排除的20篇文章中15篇系重复研究,5篇为Meta分析研究。资料综合:38篇文献中9篇对循环核酸的组成、性质及其来源加以分析。18篇从不同角度阐述循环核酸在肿瘤发生、发展及其预后中的重要作用。11篇的研究结果表明循环核酸在肺癌中的应用价值。
作者 于正洪 陈龙邦
机构地区 解放军南京军区南京总医院肿瘤内科
出处 《中国临床康复》 CSCD 2004年第35期8071-8073,共3页 Chinese Journal of Clinical Rehabilitation
关键词 肺肿瘤 核酸类 标志监测 预后
分类号 R73 [医药卫生—肿瘤]
  • 相关文献

参考文献18

  • 1[1]Peto R, Lopez AD, Boreham J, et al. Mortality from smoking worldwide. Br Med Bull 1996;52:12 -21
  • 2[2]Landis SH, Murray T, Bolden S, et al. Cancer statistics. CA Cancer J Clin 1998;48(1):6 -29
  • 3[3]Sozzi G, Musso K, Ratcliffe C, et al. Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: a prospect for early diagnosis. Clinical Cancer Research 1999 ;5:2689 - 92
  • 4[4]Stroun M, Anker P, Maurice P, et al. Neoplastic characteristics of theDNA found in the plasma of cancer patients. Oncology 1989 ;46 (5): 318 - 22
  • 5[5]Vasioukhin V, Anker P, Maurice P, et al. Point mutations of the N-ras in the blood plasma DNA of patients with myelodys plastic syndrome or acute myelogenous leukaemia. Br J Haematol 1994; 86 (4): 774 - 9
  • 6[6]Chen XQ, Stroun M, Magnenat JL, et al. Micro satellite alterations in plasma DNA of small cell lung cancer patients. Nat Med 1996;2(9): 1033 -5
  • 7[7]Nawroz H, Koch W, Anker P, et al. Miaroatellite alterations in plasma DNA of head and neck cancer patients. Nat Med 1996;2(9): 1035 -7
  • 8[8]Sozzi G, Conte D, Mariani L, et al. Analysis of circulatin tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients. Cancer Research 2001 ;61: 4675 - 8
  • 9[9]Leon SA, Shapiro B, Sklaroff DM, et al. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 1977;37(3): 646 -50
  • 10[10]Johnson P,Lo YMD.Plasma nucleic acids inthe diagnosis and management of malignant disease.Clin Chem 2002;48(8):1186-93

二级参考文献27

  • 1[1]Peto R, Lopez A D, Boreham J, et al. Mortality from smoking worldwide. Br Med Bul1, 1996, 52:12
  • 2[2]Landis S H, Murray T, Bolden S, et al. Cancer statistics, 1998,CA. Cancer J Clin, 1998, 48 (1) :6
  • 3[3]Sozzi G, Musso K, Ratcliffe C, et al. Detection of microsatellite alterations in plasma DNA of non-small cell lung cancer patients: A prospect for early diagnosis. Clinical Cancer Research, 1999, 5:2689
  • 4[4]Leon SA, Shapiro B, Sklaroff DM, et al. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res, 1977, 37 (3) :646
  • 5[5]Stroun M, Anker P, M aurice P, et al. Neoplastic characteristics of the DNA found in the plasma of cancer patients. Oncology, 1989, 46 (5):318
  • 6[6]Vasioukhin V, Anker P, MauriceP, et al. Point mutations of the N-ras in the blood plasma DNA of patients with myelodys plastic syndrome or acute myelogenous leukaemia. Br J Haematol, 1994, 86 (4) :774
  • 7[7]Chen XQ, Stroun M, Magnenat JL, et al. Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat Med, 1996, 2 (9):1033
  • 8[8]Nawroz H, Koch W, Anker P, et al. Microatellite alterations in plasma DNA of head and neck cancer patients. Nat Med, 1996, 2 (9) : 1035
  • 9[9]Sozzi G, Conte D, Mariani L, et al. Analysis of circulatin tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients. Cancer Research, 2001, 61:4675
  • 10[10]Hayashi T, Sugahara K, Dateki N, et al. Characteristics of plasma DNA and its application for detection of K2ras gene mutation. Rinsho Byori, 2000, 48 (6) :547

共引文献27

同被引文献16

  • 1Paduch R Theories of cancer origin[J].Eur J Cancer Prev,2015,24(1):57-67.
  • 2Portela A,Esteller M.Epigenetic modifications and human disease[J].Nat Biotechnol,2010,28(10):1057-1068.
  • 3Bird-Lieberman EL,Fitzgerald RC.Early diagnosis of oesoph- ageal cancer[J].BrJCancer,2009,101(1):1-6.
  • 4Shapiro B,Chakrabarty M,Cohn EM,et al.Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease[J],Cancer,1983,51(11):2116-2120.
  • 5Leon SA,Shapiro B,Sklaroff DM,et al.Free DNA in the serum of cancer patients and the effect of therapy[J],Cancer Res,1977,37(3):646-650.
  • 6Mulcahy HE,Lyautey J,Lederrey C,et al.Plasma DNA K-ras mutations in patients with gastrointestinal malignancies[J].Ann N Y Acad Sci,2000,906:25-28.
  • 7Jones PA,Baylin SB.The epigenomics of cancer[J].Cell,2007,128(4):683-692.
  • 8Wong TS,Kwong DL,Sham JS,et al.Quantitative plasma hypermethylated DNA markers of undifferentiated nasopha- ryngeal carcinoma[J].Clin Cancer Res,2004,10(7):2401-2406.
  • 9Nass SJ,Herman JG,Gabrielson E,et al.Aberrant methyla- tion of the estrogen receptor and E-cadherin 5,CpG islands increases with malignant progression in human breast cancer[J].Cancer Res,2000,60(16):4346-4348.
  • 10Suzuki N,Kamataki A,Yamaki J,et al.Characterization of circulating DNA in healthy human plasma[J].Clin Chim Acta,2008,387(1/2):55-58.

引证文献2

中国临床康复
2004年 第35期

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