摘要
目的 探讨血浆同型半胱氨酸增高对高血压并发脑梗死病人的影响。方法 入选病例 89例 ,分为单纯高血压组(对照组 ) 3 0例及与之相匹配的高血压合并脑梗死组 (观察组 ) 5 9例。测定两组病人的血浆同型半胱氨酸 (Hcy)、血糖(BG)、血脂、纤维蛋白原 (Fg)、体重指数 (BMI) ,并对两组各指标进行比较 ,分析各指标对脑梗死的影响。结果 观察组62 .7%病人Hcy增高 ,对照组2 3 .3 %病人增高 (P <0 .0 1) ,观察组Hcy值为 (2 2 .91±15 .3 9) μmol/L ,明显高于对照组 (12 .3 6± 4.5 9) μmol/L(P <0 .0 0 0 1) ;两组之间BS、血脂、Fg、MBI比较无统计学意义 (P >0 .0 5 )。Hcy增高与BG血脂、Fg、MDI无关 ;Hcy≥15 μmml/L时 ,脑血管病的优势比OR值为 5 .5 2 6(95 %CI2 .12 9～ 14 .3 4)。结论 血浆同型半胱氨酸增高是高血压并脑梗死的主要危险因素。
Objective To investigate the influence of increased plasma homocysteine (Hcy)on hypertension patients accompanied with cerebral infarction.Methods All the subjects(89)were divided into 2 groups:30 with hypertension merely as the control group and 59 with hypertension accompanied with cerebral infarction as the observation group.all the subjects were taken to check the levels of Hcy,free plasma glucose,blood lipid (including cholesterol,triglyceride,high density lipoprotern and low density lipoprotein),fibrinogen(Fg)and body mass index(BMI),then every index of the two groups was compared.Results The level of Hcy was inceased in 62.7% of the cases in the observation group and inceased in 23.3% of the cases in the control group.There was significantly different(P￡1/40.01).The mean level(22.91±15.39) μmol/L was significant higher than that in the control group (12.36?à4.59) |ìmol/L(P￡1/40.0001).However,there was no significant differences of the levels of free plasms glucose,blood-lipid,Fg and BMI among the patients of the two groups(P￡3/40.05).there was no statistical correlation between the increrse of plasma Hcy was higher than or equal to 15 μmol/L,The odd ratio(OR)of the ischenic cerbrovascular disease was 5.526(95%CI 2.129?14.34).Conclusion Hyperhomcystinemia is an important risk factor of hypertension accompanied with cerebral infarction.
出处
《中西医结合心脑血管病杂志》
2004年第12期691-692,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
同型半胱氨酸
高血压
脑梗死
homocysteine
hypertension
cerebral infarction
