摘要
目的 提高肾嗜酸细胞瘤的诊治水平。 方法 回顾分析 3例肾嗜酸细胞瘤患者的临床资料。临床无特异表现 ,肿瘤大小分别为 7.6cm× 8.5cm× 6 .8cm、10 .0cm× 11.5cm× 9.8cm、10 .0cm× 8.0cm× 6 .8cm ,分别位于左肾下极、右肾上极、右肾下极。CT扫描肿瘤密度均匀一致 ,瘤体中央有星状结构。术前均诊为肾癌而行肾癌根治术。 结果 肉眼观察瘤体边界清楚 ,切面呈棕色或棕褐色 ,均质状 ,无出血及坏死灶。光镜下瘤细胞排列成腺泡状或管状 ,胞质含丰富的嗜酸性颗粒 ,细胞无明显异型性和核分裂相。电镜下胞质内见大量线粒体。免疫组化染色 :Cytokeratin(+) ,EMA(+) ,Vimentin(- )。 3例患者随访 16～ 30个月 ,未见肿瘤复发或转移。 结论 肾嗜酸细胞瘤是一种良性实质性上皮肿瘤 ,临床无特异性 ,诊断需依据病理组织学、免疫组化及电镜特点综合判断。
Objective To improve the diagnosis and treatment of renal oncocytoma. Methods The clinical data of 3 cases with renal oncocytoma treated from 1999 to 2002 were retrospectively analyzed and discussed with literature reviewed. The 3 tumors’size was 7.6 cm×8.5 cm×6.8 cm,10.0 cm×11.5 cm×9.8 cm,10.0 cm×8.0 cm×6.8 cm,respectively.The clinical features were atypical.Renal oncocytoma was characterized by homogeneous attenuation with a central, margined stellate area on CT scan. Results The 3 cases underwent nephrectomy,and the resected tumors were examined by pathology.On light microscopy,there was strong eosinophilic cytoplasm with granules,the tumor cells being tubular or adenoid in pattern with no necrosis and very rare or no mitosis.Enormous mitochondria were noted on electron microscopy.The immunohistochemical staining was positive for cytokeratin and EMA,whereas it was negative for vimentin.The follow-up lasted for 16 to 30 months without recurrence or metastasis. Conclusions Renal oncocytoma is a type of benign,parenchymatous tumor,and it has no specific clinical feature.The diagnosis can be established on histopathologic,immunohistochemical and electron microscopic studies.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2004年第12期825-827,共3页
Chinese Journal of Urology
