摘要
目的 分析糖耐量正常的代谢综合征者的胰岛素分泌功能及胰岛素抵抗状况。方法 采用ATPⅢ的诊断标准诊断代谢综合征 19例 ,进行口服 75g葡萄糖耐量试验和胰岛素释放试验。结果 代谢综合征者空腹胰岛素及餐后 30min、6 0min、12 0min胰岛素分泌明显增加 (P分别 <0 .0 1,0 .0 5 ,0 .0 1,0 .0 5 ) ,β细胞功能明显提高(P <0 .0 5 ) ,胰岛素抵抗明显加重、胰岛素敏感性下降 (P 均 <0 .0 1)。胰岛素早期分泌也明显增加 (P <0 .0 5 )。结论 从糖耐量正常人群研究发现 ,符合ATPⅢ诊断标准的代谢综合征者也存在胰岛素抵抗、胰岛素敏感性降低、代偿性高胰岛素血症 ,ATPⅢ诊断标准也牵涉胰岛素抵抗。
Objective To analyse insulin secretion and insulin resistance in metabolic syndrome patients with normal glucose tolerance. Methods Oral 75 g glucose tolerance test and insulin secretion test were made in 19 patients with metabolic syndrome diagnosed according to ATPⅢ and having normal glucose tolerance. Results The levels of fasting insulin and insulin 30 min, 60 min and 120 min after loading with 75 g oral glucose were increased in the 19 metabolic syndrome patients(P< 0.001, 0.05, 0.01, 0.05, respectively). Their insulin resistance was serious, Insulin sensitivity was decreased, but the early secretion of insulin was increased(P<0.05). Conclusion Metabolic syndrome patients with normal glucose tolerance also have insulin resistance, decreased insulin sensitivity and hyperinsulinemia.
出处
《徐州医学院学报》
CAS
2004年第5期401-403,共3页
Acta Academiae Medicinae Xuzhou
