摘要
目的:观察橄榄解酒饮对大鼠、小鼠急性酒精性肝损伤的防治效果,初步探讨其对血清及肝匀浆丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)的影响。方法:采用白酒灌胃法造模,每天记录醉酒、醒酒时间,第3天检测血清ALT,第5天检测血清及肝匀浆ALT、AST,并与护肝胶囊对照。结果:橄榄解酒饮可显著降低大鼠、小鼠急性酒精性肝损伤模型醉酒率,提高醒/醉比;显著降低血清ALT、AST及肝匀浆ALT水平,与对照组比较差异有显著(P<0.05或P<0.01)。结论:橄榄解酒饮具有良好的防醉解酒护肝作用。
Objective: To observe preventive and therapeutic effects of Ganlan Jiejiu Yin on acute alcoholic hepatic injury in the rat and the mouse, and to study preliminarily effects on alinine transaminase(ALT) and aspartic transaminase (AST) in serum and hepatic homogenate. Methods: The acute alcoholic hepatic injury model was made by stomach perfusion of white spirit for 5 days, and drunk time and the recovering time were observed every day, and serum ALT on the 3rd day and ALT and AST in serum and hepatic homogenate on the 5th day were determined, and the results were compared with those of Hugan Capsules. Results: Ganlan Jiejiu Yin could significantly decrease the drunk rate, increase the recovery/drunk ratio, and decrease ALT and AST in serum and ALT in hepatic homogenate with significant differences as compared with those of the control group. Conclusion: Ganlan Jiejiu Yin has good drunk-preventing, alcoholism-relieving and liver-protecting actions.
出处
《中医杂志》
CSCD
北大核心
2004年第10期774-776,共3页
Journal of Traditional Chinese Medicine
基金
河南省国际合作项目(0246660002)
