摘要
目的 :研究白藜芦醇对体外培养的小鼠肝癌细胞 H2 2 生长的影响。方法 :应用MTT法、流式细胞仪来分析白藜芦醇对 H2 2 细胞生长的影响及细胞周期的变化。结果 :白藜芦醇对 H2 2 细胞的增殖具有抑制作用 ,IC5 0为 6.1 2 mg/L ,流式细胞术证实 ,白藜芦醇能引起 H2 2 细胞 S期阻滞。结论 :白藜芦醇通过改变 H2 2 细胞的细胞周期分布来抑制其生长。
Objective:To measure the effect of resveratrol on the murine hepatoma cell line H_ 22. Methods: MTT assay ,flow cytometry was used to examine growth and change of Cell cycle of H_ 22 cells . Results: Resveratrol inhibited the growth of hepatoma cells line H_ 22,IC50 of the resveratrol on H_ 22 cells was 6.12mg/L . FCM analysis revealed that resveratrol could increase the percentage of cells in S phase.Conclusions: Resveratrol has obvious antitumor activities on murine hepatoma22 through inducing of S phase arrest .
出处
《陕西医学杂志》
CAS
北大核心
2004年第11期1031-1033,共3页
Shaanxi Medical Journal
基金
陕西省中医药管理局资助 (2 0 0 1 -0 3 5 )
