Study on Drug Resistance and Relative Mechanisms of Chlamydia Trachomatis
关于沙眼衣原体耐药及耐药机制的探讨(英文)
摘要
Chlamydia Trachomatis (C.T.) is one of the most common pathogens of human sexually transmitted diseases. Treatment of C.T. infection primarily depends on Tetracyclines, Macrolides and Quinolones, but with the wide use of antibiotics an increasing number of drug-resistant Chlamydia trachomatis cases have been reported. This review summarizes the resistant conditions and the possible resistance mechanisms of C.T..
沙眼衣原体是性传播疾病中最常见的病原之一。目前临床上治疗主要依靠以四环素族、大环内酯类及喹诺酮类为主的抗生素。但随着这些抗生素的广泛应用,关于沙眼衣原体耐药的报告日渐增多,研究发现,沙眼衣原体耐药主要是由质粒介导或基因突变导致。本文就沙眼衣原体的耐药状况及可能的机制作一概述。
参考文献10
-
1Xu fusong,,Qu yachun,Wang jinsong.Study progress of epidemiology and clinical diagnosis and treatment of uro-genita‘I Chlamydia trachomatis infectious disease[].Pract J of Andrology.1997
-
2Lefevre.J,Plepargneur.Comparative in vitro susceptibility of a tetracycline-resistant Chlamydia trachomatis strain isolated in Toulouse (France)[].Sexually Transmitted Diseases.1998
-
3J.Lenart.Growth and Development of Tetracycline-Re-sistant Chlamydia suis[].Antimicrobial Agents and Chemotherapy.2001
-
4Morrissey, I,Salman,H,Bakker,S,et,al.Serial passage of Chlamydia spp.in sub-inhibitory fluoroquinolone concentrations[].Journal of Antimicrobial Chemotherapy.2002
-
5Ravi kaul,,Gart J,Gray Niels, et,al.Cloning and sequence analysis of the chlamydia trachomatis spc Ribosomal protein gene cluster[].Journal of Bacteriology.1992
-
6Graham Tipples.Isolation and Initial Characterization of a Series of Chlamydia trachomatis Isolates Selected for Hydroxyurea Resistance by a Stepwise Procedure[].Journal of Bacteriology.1991
-
7Wang,LL,Henson,E,Mcclarty,G.Characterization. of. Trimethoprim.and.Sulphisoxazole-resistant. Chlamydia. trachomatis[].Molecular Microbiology.1994
-
8Mccoy,-A-J,Sandlin,R-C-,MaureIli,-A-T.In vitro and in functional activity of Chlamydia MurA, apeptidoglycan synthesis and fosfomycin resistance[].Journal of Bacteriology.2003
-
9Somani J,Bhullar VB,Workowski KA,et al.Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure[].The Journal of Infectious Diseases.2000
-
10Dessus-babus S,Bebear CM,Charron A,et al.Sequencing of gyrase and topoisomerase IV quinolone-resistance determining regions of chlamydia trachomatis and characterization of quinolone-resistant mutants obtained in vitro[].Antimicrobial Agents and Chemotherapy.1998
-
1竺香才,王荷碧.DNA拓扑异构酶Ⅱ介导药物抗性研究进展[J].国外医学（输血及血液学分册）,1993,16(4):200-202. 被引量：1
-
2Ginsburg H,Krugliak M,杨彬.喹啉类抗疟药——作用方式、药物抗性及其逆转最新知识与未解之谜[J].国外医学（寄生虫病分册）,1993,20(3):111-114.
-
3叶润,张冬梅,潘卫庆.转基因技术在疟原虫药物抗性机制研究中的应用[J].国际医学寄生虫病杂志,2010,37(4):241-244.
-
4周学梅,都亚娟.真菌生物膜与药物抗性研究进展[J].中国预防医学杂志,2005,6(4):399-400.
-
5盛清,王满琴,何浙生.68株大肠埃希氏菌的药物抗性分析[J].浙江预防医学,1999,11(5):8-9. 被引量：1
-
6罗绍淼,李宝花.阿齐霉素治疗泌尿生殖道衣原体及支原体感染[J].贵州医药,2001,25(1):51-52. 被引量：1
-
7齐蔓莉,张楠,刘全忠.六种抗菌药物治疗非淋菌性尿道(宫颈)炎的疗效分析[J].中华皮肤科杂志,2005,38(5):313-314. 被引量：4
-
8王红枫,刘全忠,齐蔓莉.沙眼衣原体E血清型的小鼠生殖道感染模型初步研究[J].中华皮肤科杂志,2006,39(5):296-297. 被引量：9
-
9各科药物[J].国外科技资料目录（医药卫生）,2002(3):204-205.
-
10文立民.疱疹病毒对抗病毒药物抗性的回顾[J].国外医学（微生物学分册）,1995,18(1):14-16. 被引量：3
