摘要
目的 动态观察高血压对脑血流自动调节下限的影响 ,及其与脑血管病理形态改变的关系。方法 选用 80只易卒中型肾血管性高血压大鼠 (RHRSP) ,在术后不同的时间点 ,利用临界关闭压测定脑血流自动调节下限 (LLCA) ,并动脉插管测定血压和定量分析脑血管的形态变化 ,分别与正常血压对照组 (80只 )的结果进行比较。结果 RHRSP组的LLCA术后第 6周开始升高 ,第 10周后明显高于对照组 (P <0 0 5 ) ,基本稳定于 110mmHg左右。多元回归分析发现 ,LLCA的升高主要与平均动脉压呈正相关 (r=0 96 8,P <0 0 5 ) ,与脑内微动脉的中膜厚度呈正相关 (r=0 94 0 ,P <0 0 5 )。并且LLCA的变化在平均动脉压改变的中间过程最明显 ,而于平均动脉压轻度和重度升高时变化不大 ,呈“S”形改变 (R2 =0 970 1,P <0 0 5 )。结论 高血压LLCA上移主要与平均动脉压有关 ,是脑内微动脉中膜增厚的体现 ,于血压升高中期改变最为明显。
Objective To dynamically study the effect of experimental hypertension on lower limit of cerebral autoregulation (LLCA), and the relationship between LLCA and blood pressure and cerebral arterial morphological changes. Methods The LLCA of stroke prone renovascular hypertensive rats (RHRSP) was determined with critical closing pressure at different time point after operation. The femoral blood pressure was simultaneously recorded by physiological multimeter, and the morphology of middle cerebral artery and arteriole was evaluated quantificationally. Results The LLCA of RHRSP began to increase at the sixth week and was as approximately 110 mmHg after tenth week, significantly higher than that of control( P <0 05). The shifting of LLCA was primarily correlative to the increase of mean arterial blood pressure ( r =0 968, P <0 05) and thickening medial membrane of cerebral arterioles ( r=0 940, P <0 05). The increase of LLCA was abrupt during the intergrade of rising of the blood pressure, but gentle at the first beginning and during the period when the blood pressure rise acutely, showing an S pattern ( R 2= 0 970 1 , P <0 05). Conclusions The increase of LLCA in hypertensive rats is primarily correlated to the rise of the mean blood pressure and is also relative with the thickning of medial membrane in cerebral arterioles.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2004年第6期423-426,i008,共5页
Chinese Journal of Nervous and Mental Diseases
基金
"2 11工程"基金 (编号 :0 61)
博士点基金 (编号 :995 0 )资助
关键词
脑血流自动调节
高血压
大鼠
Cerebral blood autoregulation Hypertension Rat
