摘要
目的 应用定量组织速度成像 (QTVI)技术检测犬不同程度急性心肌缺血前后左室前壁心肌运动速度和应变率 (SR)的变化 ,探寻一种能定量、敏感、无创性地评价左室局部收缩及舒张功能的新方法。方法 将 9只开胸犬冠状动脉左前降支 (LAD)血流减少造成中度、重度心肌缺血模型 ,取左室乳头肌水平短轴观 ,以QTVI分别检测不同程度缺血时左室前壁心内膜下心肌和心外膜下心肌收缩期峰值运动速度 (Vsendo、Vsepi)、舒张早期峰值运动速度 (Veendo、Veepi) ,并计算出收缩期SR (SRs)和舒张早期SR(SRe)。结果 基础状态下 ,心内膜下心肌速度高于心外膜下心肌速度。缺血导致左室前壁Vsendo、Veendo、Veepi和SRe均显著下降 ,尽管Vsepi降低不明显 ,但SRs降低显著。 结论 心肌运动速度和应变率能敏感地评价不同程度实验性心肌缺血 ,比常规的方法 (运动幅度和室壁增厚率 )
Objective By using quantitative tissue velocity imaging(QTVI),to explore myocardial velocities and strain rates(SR) in detection of the anterior wall of left ventricle before and after different acute ischemia for a quantitative,sensitive and non-traumatic new method assessing the local contraction and diastolization of left ventricle. Methods Moderate and severe degrees of myocardial ischemia resulted from less blood flow in left anterior descending artery(LAD) of 9 open-chest canine models.In the parasteral short-axis view at the mid-papillary muscle level, myocardial velocities were assessed within endocarium and epicardium of the anterior and posterior wall by QTVI, SR was calculated. Results At baseline, endocardial velocities were higher than epicardial velocities. In the anterior wall, ischemia caused a significant reduction in systolic and early diastolic velocities in endocardium, in early diastolic velocities in epicardium and in SR. The peak systolic velocities in epicardium slightly but not significantly decreased. Conclusions Myocardial velocities and SR quantifies different degrees of experimental ischemia more sensitively than the routine method.
出处
《中华超声影像学杂志》
CSCD
2004年第10期774-776,共3页
Chinese Journal of Ultrasonography
关键词
左室
心肌缺血
心内膜
心外膜
早期
开胸
无创性
短轴
运动速度
峰值
Echocardiography
Myocardial ischemia
Ventricular function,left
Tissue velocity imaging
Strain rate
