摘要
促血管生成素(Angiopoitins)促进血管发生、重塑、成熟和维持,与肿瘤、炎症的血管发生,与肿瘤细胞的增殖和转移有密切关系,其家族成员包括 Angiopoitinl、2、3、4。Ang 1通过活化 Tie2受体促进血管发生,具有抗凋亡、抗缺血、抗炎等效应。Ang 2和内皮细胞生长因子协调促进血管发生,高压氧和缺氧能调节 Ang 2表达。Ang 2促进胶质瘤细胞增殖,这种作用是通过活化 MMP-2所引起。抑制 Angs/Tie 2信号转导级联反应是治疗肿瘤有前景的方法。
Angiopoietins promote angiogenesis,remodeling,maturation and maintenance in blood vessel, and are closely correlated with inflammatory angiogenesis and proliferation and metastasis of tumor cells,including Angiopoitinl、2、3、4.Angl promotes angiogenesis through activation of Tie2 receptor,having effect of anti-apopto- sis,anti-isehemia and anti-inflammation.Ang2 and VEGF may have synergy for angiogenesis.The expression of Ang2 can be regulated by hyperbaric oxygen and hypoxia.Ang2 promotes proliferation of glioma cells,which depends on activation of MMP-2.Inhibition of signal transducted aseade reaction of Angs/Tie 2 is a promising method of treating tumor.
出处
《中国神经肿瘤杂志》
2004年第3期232-236,共5页
Chinese Journal of Neuro-Oncology
