摘要
目的 :观察肉苁蓉水提液对 D-半乳糖致衰大鼠肝脏氧化损伤的保护作用。方法 :采用 D-半乳糖所致衰老模型大鼠 ,灌服肉苁蓉水提液 6周 ,测定肝脏活性氧单位、Ca2 + - ATP酶活性、肝线粒体 MDA含量、PL A2 活性。结果 :肉苁蓉水提液显著提高衰老模型大鼠肝脏活性氧单位、Ca2 + - ATP酶活性 (P <0 .0 1) ,显著降低肝线粒体 MDA含量、PL A2 活性(P<0 .0 1)。结论 :肉苁蓉水提液能提高衰老模型大鼠肝脏抗氧化能力 。
Objective: To investigate the anti- oxidation effects of water extract of desertliving cistanche on liver mitochondria of aging model rat induced by D-gal. Methods: We used the aging rat induced by D-gal as research sample given water extract of desertliving cistanche for 6 week. We measured the active oxygen unit and Ca 2+-ATPase activity in rat liver and determined the MDA content,and PLA 2 activity in rat liver mitochondria in an attempt to study the effects of water extract of desertliving cistanche on the above-mentioned indexes. Results: The active oxygen unit, Ca 2+-ATPase activity were obviously increased (P<0.01),while the MDA content and PLA 2 activity were markedly decreased (P<0.01)by giving the water extract of desertliving cistanche. Conclusion: The water extract of desertliving cistanche can postpone aging by raising the liver anti- oxidation function of aging model rat.
出处
《黑龙江医药科学》
2004年第5期22-23,共2页
Heilongjiang Medicine and Pharmacy
关键词
肉苁蓉
致衰大鼠
肝脏
氧化损伤
线粒体
desertliving cistanche
aging rat
liver
oxidative damage
mitochondrion
