摘要
目的 对水飞蓟素纳米粒载体材料和制备方法进行了初步筛选。方法 以平均粒径、包封率、载药量和表面形态作为评价指标,考察了水飞蓟素纳米粒载体材料和制备方法。结果 固体脂质纳米粒(SLN)具有较高的包封率,纳米粒呈片状;乳酸/乙醇酸共聚物(PLGA)纳米粒粒径分布较均匀;纳米脂质体形成较少。结论 选择山榆酸甘油酯作为制备水飞蓟素纳米粒的载体材料,采用高压乳匀法制备水飞蓟素SLN是较为理想的方法。
OBJECTIVE To study the materials and preparation of silymarin-loaded nanoparticles preliminarily. METHODS Materials and preparation of silymarin-loaded nanoparticles were selected by mean diameter, entrapment efficiency, drug loading, and morphology. RESULTS Solid lipid nanoparticles had better entrapment efficiency and it was sheet-shaped. PLGA nanoparticles had narrow size distribution. However, nanoliposomes was hardly formed. CONCLUSIONS Compritol 888 ATO was a good material for preparing silymarin-loaded nanoparticles, and high pressure homogenization may be used to prepare the silymarin-loaded SLN.
出处
《中南药学》
CAS
2004年第5期259-261,共3页
Central South Pharmacy
基金
国家"863"计划项目(2001AA218011)
上海市纳米科技与产业发展促进中心项目(0143nm063)
关键词
固体脂质纳米粒
水飞蓟素
山榆酸甘油酯
高压乳匀法
solid lipid nanoparticles
silymarin
compritol 888 ATO
high pressure homogenization
