摘要
目的 采用心肌灌注显像等方法评价Nd:YAG激光心肌血运重建术(TMLR)治疗实验性急性心肌梗死(AMI)的作用。方法将24条犬随机等分为AMI对照组和TMLR治疗组。术后行99m锝(Tc)-MIBI心肌灌注显像和靶心图定量测定缺损分数(DF),TTC染色测梗死面积／左室面积(IS／LV),以及生存分析和心肌组织学检查。结果对照组和治疗组DF分别为(0.35±0.05)和(0.31±0.04),两组差异有显著性(P<0.05);IS／LV分别为(0.18±0.06)和(0.07±0.041),(P<0.01);DF与IS／LV呈正相关(r=0.475,P<0.05)。对照组和治疗组生存期分别为(18.0±2.7)d和(51.3±3.4)d,差异有非常显著性(P<0.01)。结论TMLR能有效改善缺血心肌血流灌注和缩小MI范围,提高AMI动物生存率。
Objective To evaluate the therapeutic effect of transmyocardial laser revascularization (TMLR) induced by Nd:YAG laser for the experimental acute myocardial infarct (AMI) in dogs using myocardial image tomograph. Methods Twenty-four dogs divided randomly and evenly into the control group of the AMI and the experimental group of the TMLR were subjected to 99mTc-MIBI SPECT imaging, and the radioactive defect fraction (DF) of the left ventricle using Bull's eye analysis and the ratio of the infarct size to the left ventricle (IS/LV) by TTC method was measured post-operation. HE staining was also done and survival of dogs was evaluated. Results 99mTc-MIBI SPECT imaging showed DF was respectively (0.35 ± 0.05, n =9) in the AMI and (0.31 ±0.04, n = 12) in the TMLR, P<0.05.TTC method revealed IS/LV were respectively (0.1810.06, n = 8) in the AMI and (0.07 ±0.04, n = 11) in the TMLR, P< 0. 01. Compared with DF, IS/LV was smaller, but there was a positive relationship between them (r = 0.475, P<0.05).The survival time was respectively (18.0 ±2.7) days in the AMI and (51.3 ±3.4) days in the TMLR, P<0.01.Conclusion TMLR could effectively increase the supplies of blood to the ischemic myocardium, decrease the infarct areas, and raise survival rate of animals with AMI.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2004年第9期1035-1036,共2页
Chinese Journal of Experimental Surgery
基金
广东省自然科学基金资助项目(950318)
