摘要
目的 观察波利特 (雷贝拉唑 )治疗胃食管返流病 (GERD)的临床疗效。 方法 随机将 80例 GERD患者分为两组 ,治疗组 4 0例 ,给予波利特 10 mg,口服 ,每日 1次 ;对照组 4 0例 ,给予奥美拉唑 2 0 mg,口服 ,每日 1次 ;疗程 8周。记录服药前后病人烧心、反酸、胸骨后灼痛等症状积分的改变 ,按症状积分下降值及内镜检查结果对比分析疗效。结果 治疗组的 GERD患者服药后 1d、 3d、 7d、 14 d、 2 8d症状积分下降值分别为 13.9± 6 .4、 10 .8± 6 .6、 9.7± 5 .7、 6 .3± 5 .7、 5 .4± 4 .9;而对照组分别为 14 .4± 5 .3、 14 .1± 5 .7、 13.9± 5 .2、 13.6± 5 .9、 7.8± 5 .1;两者的差异有显著性 (P<0 .0 5 )。治疗组和对照组的食管黏膜损害愈合率分别为 72 .5 %和 6 2 .5 % ,有效率为 97.5 %和 92 .5 % ,差异均无显著性意义 (P>0 .0 5 )。 结论 波利特是一种治疗胃食管返流病速效且安全的质子泵抑制剂(PPI)。
objective to observe the clinical efficiency of rabeprazole in treating gastro-esophageal reflex disease (GERD).Methods Eighty GERD patients was randomly divided into two groups:forty patients in the treatment group were treated with rabeprazole 10 mg,po,qd,and the forty patients in the control group were treated with omeprazole 20 mg,po,qd.The whole cause lasted for eight weeks.Symptom score from heartburn,acid regurgitation,and substemal pain etc,was recorded before and after taking rabeprazole or omeprazole.The analysis of the efficiency is according to the symptom score decreasing and the results of the endoscopy.Results The symptom score decreasing after taking medicine one day,three days,seven days,14 days,28 days was 13.9±6.4,12.8±6.6,9.7±5.7,6.3±5.7,5.4±4.9 in the treatment group,and 14.4±5.3,14.1±5.7,13.9±5.2,13.6±5.9,7.8±5.1 in the control group.The difference was remarkable (P<0.05).The healing rate in esophageal mucosal damage was 72.5% in the treatment group and 62.5% in the control group,while the effective rate was 97.5% and 92.5% respectively.The difference was unremarkable(P>0.05).Conclusion Rabeprazol is a save proton pump inhibitor in the treatment of GERD and provides fast symptoms relief.
出处
《福建医药杂志》
CAS
2004年第4期27-29,共3页
Fujian Medical Journal
